Combining Selenocystine Based Fluorescence Assay with Structural Prediction for Enhanced Detection and Analysis of Cystine Stone Pathology
Xiaobai He, Xinyi Qian, Xiaoguang Zheng, Hong Zhang, Jinbang Shao, Xiaopan Chen, Ruan Qi, Jianxin Lyu, Leixiang Yang, Linjie Chen
The paper develops a nonradioactive assay combining selenocystine fluorescence and AlphaFold for diagnosing cystinuria mutations and analyzing their functional impacts.
bioRxiv · Aug 29, 2025 · PreprintGenetics