History of Traumatic Brain Injury with Loss of Consciousness and APOE ϵ4 Carriers Synergistically Increase Late-Life Amyloid PET Burden
Jeremy F. Strain, Nicolas R. Barthélemy, Ruchira Jha, Owen Guo, Madhur Parihar, Kyle Chan, Babatunde Adeyemo, Peter R Millar, Kyle B. Womack, Brian Andrew Gordon, Suzanne E. Schindler, John C. Morris, Tammie L.S. Benzinger, Beau M. Ances, Chia‐Ling Phuah
This study finds that a history of traumatic brain injury with loss of consciousness (TBI-LOC) increases late-life amyloid PET burden, especially in APOE ε4 carriers with no clinical dementia.
bioRxiv · Apr 20, 2026 · PreprintNeuroscience