Nicolas R. Barthélemy

The paper characterizes big tau isoforms in human nervous system tissues and CSF, finding they are enriched in the peripheral nervous system and largely unaffected by neurodegenerative disease.

This study evaluates how biomarker variability affects individualized amyloid time estimation in Alzheimer's disease, finding that inter-individual variability is the main source of error.

This study finds that a history of traumatic brain injury with loss of consciousness (TBI-LOC) increases late-life amyloid PET burden, especially in APOE ε4 carriers with no clinical dementia.

The paper shows that hyperphosphorylation of tau at T217 in cerebrospinal fluid is specifically linked to amyloid-β pathology in Alzheimer's disease.