Author

Kyle Chan

Barrow Neurological Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Aleksandra Judina· 1 shared Alina Zorn· 1 shared Ao LiiD· 1 shared Babatunde Adeyemo· 1 shared Beau M. AncesiD· 1 shared Brian Andrew GordoniD· 1 shared Cathy Swindlehurst· 1 shared Chia‐Ling PhuahiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aleksandra Judina

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling

Aleksandra Judina, Zhiyao Shi, Jiarong Fu, Ivan Sherstnev, Veronika Boichenko, Jiayue Ling, Madihah Hussain, Alina Zorn, Yuan Yan Sin, Houcheng Wang, Ao Li, Sasha Korogodski, Eduardo Torres, David Stirling, Kyle Chan, , Julia Gorelik

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

bioRxiv · Nov 2, 2026 · PreprintPharmacology & Toxicology

History of Traumatic Brain Injury with Loss of Consciousness and APOE ϵ4 Carriers Synergistically Increase Late-Life Amyloid PET Burden

Jeremy F. Strain, Nicolas R. Barthélemy, Ruchira Jha, Owen Guo, Madhur Parihar, Kyle Chan, Babatunde Adeyemo, Peter R Millar, Kyle B. Womack, Brian Andrew Gordon, Suzanne E. Schindler, John C. Morris, Tammie L.S. Benzinger, Beau M. Ances, Chia‐Ling Phuah

This study finds that a history of traumatic brain injury with loss of consciousness (TBI-LOC) increases late-life amyloid PET burden, especially in APOE ε4 carriers with no clinical dementia.

bioRxiv · Apr 20, 2026 · PreprintNeuroscience