A neuropsychiatric disease-associated mutation in LRRC8B disrupts cellular calcium signaling, mitochondrial function, and bioenergetics
Athira Ajith, Durai Shalu S, Rudrakant Sharma, Amit Kumar Ghosh, Amal Kanti Bera
This paper investigates a neuropsychiatric disease-associated mutation in LRRC8B, showing it disrupts calcium signaling, mitochondrial function, and bioenergetics through interactions with VDAC.
bioRxiv · Apr 17, 2026 · PreprintCell Biology