The membrane topology problem inherent in ciliogenesis is solved by ciliary recruitment of a phospholipid flippase
Zhengmao Wang, Ruida He, Qingqing Liu, William J. Snell, Muqing Cao, Junmin Pan
This paper identifies a membrane topology problem in ciliogenesis and shows that the phospholipid flippase ALA2 resolves it by flipping phosphatidyl ethanolamine to establish ciliary membrane curvature.
bioRxiv · Jan 13, 2025 · PreprintCell Biology