Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models
Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Meng-Hao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu
The paper introduces CHOOSER, a foundation model-based framework for discovering CRISPR-Cas systems with self-processing pre-crRNA capability, identifying 11 novel homologs and validating one for functional use.
Nature Communications · Nov 19, 2024Peer-reviewedBioinformatics