Author

Peixiang Ma

ShanghaiTech UniversityORCID 0000-0001-6794-1663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Jia LiuiD· 2 shared Bei YangiD· 1 shared Biao JiangiD· 1 shared Bing MengiD· 1 shared Guang YangiD· 1 shared Guohui ChuaiiD· 1 shared Jie LiiD· 1 shared Jin TangiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Jia LiuORCID

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3 papers

Recent·Most cited

Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Meng-Hao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

The paper introduces CHOOSER, a foundation model-based framework for discovering CRISPR-Cas systems with self-processing pre-crRNA capability, identifying 11 novel homologs and validating one for functional use.

Nature Communications · Nov 19, 2024Peer-reviewedBioinformatics

Phage Peptides Mediate Precision Base Editing with Focused Targeting Window

Kun Jia, Yanru Cui, Shisheng Huang, Peihong Yu, Zhengxing Lian, Peixiang Ma, Jia Liu

This study uses a bacteriophage-derived peptide to control CBE activity, improving targeting precision and gene correction efficiency in a Marfan syndrome model.

Nature Communications · Mar 29, 2022Peer-reviewedGenomics

Allosteric Inhibition of CRISPR-Cas9 by Bacteriophage-derived Peptides

Yan-ru Cui, Shao-jie Wang, Jun Chen, Jie Li, Wenzhang Chen, Shuyue Wang, Bing Meng, Wei Zhu, Zhuhong Zhang, Bei Yang, Biao Jiang, Guang Yang, Peixiang Ma, Jia Liu

The paper identifies bacteriophage-derived peptides that allosterically inhibit CRISPR-Cas9 activity, reducing off-target effects while preserving on-target activity.

Genome biology · Feb 26, 2020Peer-reviewedGenomics