Manganese suppresses tumor growth through hyper-activating IRE1α
Ruoxi Shi, Ming Wang, Si Chen, Xiangming Hu, Xudong Zhao, Shixin Zhou, Congli Fan, Zihan Zhou, Likun Wang
This study identifies manganese as an IRE1 activator that suppresses tumor growth by inducing apoptosis through the unfolded protein response pathway.
iScience · Jul 16, 2025Peer-reviewedCancer Biology