Automated multiscale high-content imaging connects plaque population heterogeneity to localized synapse loss
Celia A. McKee, Russell Port, Mackenzie Hofmann, Sean Smith, Xiaohai Wang, Rebecca Klein, Michael Marino
The paper develops an automated high-content imaging workflow to quantify synapse loss associated with amyloid beta plaques in mouse brains, finding that large cored plaques primarily drive synapse loss.
bioRxiv · Oct 31, 2026 · PreprintNeuroscience