Celia A. McKee

Automated multiscale high-content imaging connects plaque population heterogeneity to localized synapse loss

The paper develops an automated high-content imaging workflow to quantify synapse loss associated with amyloid beta plaques in mouse brains, finding that large cored plaques primarily drive synapse loss.

The astrocyte clock controls circadian perineuronal net remodeling, synapse strength and learning behavior

This study shows that astrocyte-specific deletion of Bmal1 disrupts circadian rhythms in perineuronal nets, synaptic plasticity, and learning behavior.

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

This study shows that traumatic brain injury causes severe and prolonged meningeal lymphatic dysfunction, leading to increased neuroinflammation and cognitive deficits.

Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.