Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence
Elena L. Haarer, Corey J. Theodore, Shirley Guo, Ryan B. Frier, Kenneth G. Campellone
This study shows that inactivating the Arp2/3 complex in mouse fibroblasts causes genomic instability, micronuclei formation, and cellular senescence due to mitotic defects.
PLoS Genetics · Jan 27, 2023Peer-reviewedGenetics