Kenneth G. Campellone

Synphilin-1 mitigates autophagy dysfunction, modulates ubiquitinated protein aggregation, and promotes cell survival during proteotoxic stress

This study shows Synphilin-1 helps cells survive proteotoxic stress by managing ubiquitinated protein aggregation and autophagy dysfunction in WHAMM/JMY knockout fibroblasts.

MYOSIN IIA MOTOR REGULATES ATTACHING-EFFACING BACTERIA INTERACTIONS WITH INTESTINAL EPITHELIUM

This study shows that NM IIA limits A/E bacterial colonization by inhibiting actin pedestal formation, while NM IIC does not play a similar role.

Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity

This study shows that the Arp2/3 complex is essential for lysosomal integrity during autophagy, as its absence leads to lysosomal damage and impaired autophagic flux.

Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

This study shows that inactivating the Arp2/3 complex in mouse fibroblasts causes genomic instability, micronuclei formation, and cellular senescence due to mitotic defects.