Multiple molecular and cellular properties jointly affect protein and site-specific evolutionary rates
Anshul Saini, Dinara R. Usmanova, Rydberg Supo Escalante, Dennis Vitkup
The paper uses neural networks to predict protein evolutionary rates by integrating molecular and cellular features across multiple scales, showing that protein-level and site-level properties contribute additively to evolutionary rate variance.
bioRxiv · May 23, 2026 · PreprintEvolutionary Biology