Luis Aparicio

This study shows that targeting CD73-A2aR adenosine signaling with radiotherapy and checkpoint inhibitors improves tumor control by overcoming radioresistance and enhancing antitumor immunity.

Smoother integrates positional information into non-spatial models for spatial omics data, enabling accurate imputation, deconvolution, and dimensionality reduction in simulated and real datasets.

This study creates a single-cell atlas of mouse and human prostate epithelium, identifying conserved progenitor populations and anatomical relationships between species.

This paper identifies a universal pattern in single-cell sequencing data and proposes a method to denoise it by distinguishing biological signals from artifacts.