Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system
Poppy Datta, Kun-Do Rhee, Rylee J Staudt, Jacob M. Thompson, Ying Hsu, Salma Hassan, Arlene V. Drack, Seongjin Seo
This paper describes a method to deliver large genes using AAV vectors and the CRE-lox system, enabling efficient reconstitution of therapeutic genes beyond AAV packaging limits.
Human Molecular Genetics · Sep 26, 2024Peer-reviewedMolecular Biology