Natriuretic Peptide Augmentation Attenuates Renin Cell Hyperactivation and Afferent Arteriolar Hypertrophy During Long-Term Renin-Angiotensin System Inhibition
Tomomi Shiiya, Hirofumi Watanabe, Ryo Aida, Chihiro Sakurazawa, Mizuki Honda, Yasuyuki Ohkawa, Shinya Oki, Tadashi Otsuka, Ryohei Kaseda, Shin Goto, Ichiei Narita, Suguru Yamamoto
This study shows that augmenting natriuretic peptide signaling with ARNI reduces renin cell activation and afferent arteriolar hypertrophy during RAS inhibition, preserving therapeutic benefits.
bioRxiv · Jul 24, 2026 · PreprintPhysiology