Author

Tadashi Otsuka

Niigata UniversityORCID 0000-0002-0572-3764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Chihiro Sakurazawa· 1 shared Hirofumi WatanabeiD· 1 shared Ichiei NaritaiD· 1 shared Mizuki HondaiD· 1 shared Ryo Aida· 1 shared Ryohei KasedaiD· 1 shared Shin GotoiD· 1 shared Shinya OkiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Chihiro Sakurazawa

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1 paper

Recent·Most cited

Natriuretic Peptide Augmentation Attenuates Renin Cell Hyperactivation and Afferent Arteriolar Hypertrophy During Long-Term Renin-Angiotensin System Inhibition

Tomomi Shiiya, Hirofumi Watanabe, Ryo Aida, Chihiro Sakurazawa, Mizuki Honda, Yasuyuki Ohkawa, Shinya Oki, Tadashi Otsuka, Ryohei Kaseda, Shin Goto, Ichiei Narita, Suguru Yamamoto

This study shows that augmenting natriuretic peptide signaling with ARNI reduces renin cell activation and afferent arteriolar hypertrophy during RAS inhibition, preserving therapeutic benefits.

bioRxiv · Jul 24, 2026 · PreprintPhysiology