The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components
Machiko Teramoto, Ryo Sugawara, Katsura Minegishi, Masanori Uchikawa, Tatsuya Takemoto, Atsushi Kuroiwa, Yasuo Ishíi, Hisato Kondoh
This study shows that SOX2 deficiency in the anterior foregut of mouse embryos leads to the transformation of esophageal and mesenchymal tissues into tracheal and bronchial structures.
Biology Open · Jan 1, 2020Peer-reviewedDevelopmental Biology