GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
Markus Terrey, Scott I. Adamson, Alana L. Gibson, Tianda Z. Deng, Ryuta Ishimura, Jeffrey H. Chuang, Susan L. Ackerman
This study shows that GTPBP1 resolves ribosome pausing caused by tRNA deficiency in the mouse brain, preventing neurodegeneration and highlighting the role of translational GTPases in neuronal homeostasis.
eLife · Nov 13, 2020Peer-reviewedNeuroscience