Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes
Alvin Hsu, Peter J. Chen, Angus H. Li, Colin F. Hemez, Xin D. Gao, Markus Terrey, C Nelson, Vijay Selvam, Ana Cristian, Amber N. McElroy, Benjamin J. Steinbeck, Gandhar K. Mahadeshwar, Smriti Pandey, Zachary Barsdale, Paul Chen, , David R. Liu
OptiPrime predicts prime editing outcomes with high accuracy, enabling efficient therapeutic applications in human and mouse cells.
bioRxiv · Feb 20, 2026 · PreprintBiochemistry