Author

Sébastien Letort

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Organism:Arabidopsis· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anne BolandiD· 3 shared Benjamin Grenier‐BoleyiD· 3 shared Camille Charbonnier-Le Clézio· 3 shared Céline BellengueziD· 3 shared Christian Dina CiD· 3 shared Claude FéreciD· 3 shared Delphine Bacq· 3 shared Dominique CampioniD· 3 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Anne BolandORCID

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Author profile →

4 papers

Recent·Most cited

SURFBAT: a surrogate family-based association test building on large imputation reference panels

Anthony F. Herzig, Simone Rubinacci, Gaëlle Marenne, Hervé Perdry, Emmanuelle Génin, Dominique Campion, Jean‐François Dartigues, Jean‐François Deleuze, Jean‐Charles Lambert, Richard Redon, Thomas E Ludwig, Benjamin Grenier‐Boley, Sébastien Letort, Pierre Lindenbaum, Vincent Meyer, , Olivier Delaneau

SURFBAT approximates transmission-disequilibrium tests using imputed haplotypes to detect genotype-phenotype associations while being robust to population stratification.

G3 Genes Genomes Genetics · Dec 9, 2024Peer-reviewedGenetics

Can imputation in a European country be improved by local reference panels? The example of France

Anthony F. Herzig, Lourdes Velo‐Suárez, Principal Investigators, Dominique Campion, Jean‐François Dartigues, Jean‐Charles Lambert, Collaborators, Bioinformatics, Thomas Ludwig, Benjamin Grenier‐Boley, Sébastien Letort, Pierre Lindenbaum, Vincent Meyer, Olivier Quenez, Statistical genetics, , Emmanuelle Génin

The paper evaluates whether using a local reference panel improves imputation accuracy in French individuals compared to a public reference panel, showing benefits of combining both approaches.

Scientific Reports · Jan 3, 2024Peer-reviewedGenetics

Large genomic variants reveal unexplored intraspecific diversity in Brassica rapa genomes

Julien Boutte, Loeiz Maillet, Thomas Chaussepied, Sébastien Letort, Jean‐Marc Aury, Caroline Belser, Franz Boideau, Anael Brunet, Olivier Coriton, Gwenaëlle Deniot, Cyril Falentin, Virginie Huteau, Maryse Lodé‐Taburel, Jérôme Morice, Gwenn Trotoux, , Julie Ferreira de Carvalho

The paper investigates structural genomic variants and repetitive content in Brassica rapa genomes using long-read sequencing and optical mapping, revealing significant intraspecific diversity in genome size and structure.

bioRxiv · Jul 2, 2020 · PreprintGenomics

Integrated Clinical and Omics Approach to Rare Diseases: Novel Genes and Oligogenic Inheritance in Holoprosencephaly

Artem Kim, Clara Savary, Christèle Dubourg, Wilfrid Carré, Charlotte Mouden, Houda Hamdi‐Rozé, Hélène Guyodo, Jérôme Le Douce, Emmanuelle Génin, Dominique Campion, Jean‐François Dartigues, Jean‐François Deleuze, Jean‐Charles Lambert, Richard Redon, Thomas E Ludwig, , Tania Attié‐Bitach

This study identifies novel HPE genes and oligogenic inheritance patterns in holoprosencephaly by integrating clinical data with exome sequencing and gene prioritization.

Brain · Oct 29, 2018Peer-reviewedGenetics