CRISPR-Cas9 editing induces Loss of Heterozygosity in the pathogenic yeast Candida parapsilosis
L. Lombardi, S. A. Bergin, A. Ryan, G. Butler
This study shows CRISPR-Cas9 editing in Candida parapsilosis can induce loss of heterozygosity and aneuploidy, highlighting the need for mutation complementation to confirm phenotypic changes.
bioRxiv · Aug 15, 2022Microbiology