Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
S. A. McMahon, W. Zhu, S. Graham, R. Rambo, M. F. White, T. M. Gloster
This paper describes the structure and mechanism of Can1, a cOA-activated CRISPR defence DNA nuclease, showing how cA4 binding activates its DNA nicking activity.
bioRxiv · Sep 26, 2019Biochemistry