W. Zhu

Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.

TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

The RNA-binding protein RbpB is a central regulator of polysaccharide utilization in gut Bacteroides

This study identifies RbpB as a key RNA-binding protein regulating polysaccharide utilization in gut Bacteroides through post-transcriptional control of PULs.

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

This study identifies AP-2 and AP-2β as critical regulators of adult epidermal homeostasis, showing their roles in keratinocyte differentiation and preventing skin inflammation.

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

This study uses genome editing in adult mice with a MIR96 mutation to restore hearing, showing efficacy that improves with earlier intervention.

Adaptive immunity: from CRISPR to CRIHSP?

The paper identifies CRIHSP structures in human adaptive immunity genes, showing their association with genomic instability and recombination.

Cardiac disease diagnosis based on GAN in case of missing data

This paper proposes AGAN, a GAN-based method for filling missing data in cardiac disease datasets, improving data quality and downstream classification accuracy.

Metabolomics-assisted mechanism analysis of gamma-PGA synthesis regulated by PhoP in B. licheniformis

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

Single cell RNA analysis uncovers the cell differentiation trajectories and functionalization for air breathing of frog lung

This study uses single-cell RNA sequencing to identify cell types and differentiation trajectories in frog lungs, revealing functionalization for air breathing and evolutionary insights.

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.

GDF15 is a Critical Renostat in the Defense Against Hypoglycemia

This study identifies GDF15 as a new hypoglycemia counterregulatory hormone, showing it increases hepatic gluconeogenesis through renal release and beta-adrenergic receptor-2 signaling.

Soil intake modifies the gut microbiota and alleviates ovalbumin-induced mice asthma inflammation

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

Endothelial-specific reduction in Arf6 impairs insulin-stimulated vasodilation and skeletal muscle blood flow resulting in systemic insulin resistance

This study shows that reducing Arf6 in endothelial cells impairs insulin-stimulated vasodilation and causes systemic insulin resistance.

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in mice

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection

This study identifies MPL36 as a major plasminogen receptor in pathogenic Leptospira, showing its role in virulence through plasmin generation and host cell interaction.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

In vitro screening of non-antibiotic alternative growth promoter combinations in broilers

This study screens six non-antibiotic growth promoter combinations in vitro to improve feed efficiency and broiler health by evaluating digestibility, microbiota, and antioxidant capacity.

Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

The paper identifies an extended gradient of Th17 activity in human CCR6+ Th cells, showing both stable phenotypes and plasticity under different activation conditions.

Effects of nonantibiotic alternative growth promoter combinations on nutrient utilization, digestive enzyme activity, intestinal morphology, and cecal microflora of broilers

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy

This study evaluates the impact of Fcγ receptor affinity on CAR T cell efficacy and safety, finding that moderate affinity provides optimal antitumor activity while high affinity causes toxicity.

Tissue-Specific and Interorgan Metabolic Reprogramming Maintains Tolerance to Sepsis

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors

This study shows that STAT5ab in stromal cells regulates niche factors critical for hematopoietic progenitor maintenance and function.

Taxonomic and metagenomic analyses define the development of the microbiota in the chick

This paper tracks microbiota development in chicks using taxonomic and metagenomic analyses, showing pathogen-induced changes and identifying amino acid biosynthesis as critical for Salmonella colonization.

Commensal Neisseria species share immune suppressive mechanisms with Neisseria gonorrhoeae

This study shows that commensal Neisseria species use similar immune suppressive mechanisms to Neisseria gonorrhoeae to inhibit T cell responses.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.