Structural basis of the Cope rearrangement and C-C bond-forming cascade in hapalindole/fischerindole biogenesis
S. A. Newmister, S. Li, M. Garcia-Borras, J. N. Sanders, S. Yang, A. N. Lowell, F. Yu, J. L. Smith, R. M. Williams, K. N. Houk, D. H. Sherman
This paper reports the structure of HpiC1, a Stig cyclase involved in hapalindole/fischerindole biosynthesis, revealing its dimeric assembly and key residues for catalytic steps.
bioRxiv · Aug 8, 2017Biochemistry