R. M. Williams

An optical aptamer-based cytokine nanosensor detects macrophage activation by bacterial toxins

This paper develops an optical cytokine nanosensor using SWCNT and IL-6-specific aptamers to detect macrophage activation by bacterial toxins with high sensitivity and rapid response.

Rapid differentiation of estrogen receptor status in patient biopsy breast cancer aspirates with an optical nanosensor

This paper develops an optical nanosensor using carbon nanotubes to rapidly detect estrogen receptor status in breast cancer biopsies with high accuracy.

Noninvasive Injectable Optical Nanosensor-Hydrogel Hybrids Detect Doxorubicin in Living Mice

This paper develops a noninvasive optical nanosensor-hydrogel hybrid that detects doxorubicin in live mice, showing stability and functionality over several weeks.

Imaging optically thick tissues simply and reproducibly: a practical guide to Lightsheet Macroscopy

The paper provides practical guidelines for mounting and imaging cleared tissues using lightsheet microscopy in standardized optical cuvettes, improving reproducibility and cost-effectiveness.

Edaravone-Loaded Mesoscale Nanoparticles Treat Cisplatin-Induced Acute Kidney Injury

This study develops edaravone-loaded mesoscale nanoparticles for treating cisplatin-induced acute kidney injury, showing improved renal function and reduced oxidative stress in mice.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

Structure of nucleotide-bound Tel1ATM reveals the molecular basis of inhibition and structural rationale for disease mutations

The paper presents the structure of nucleotide-bound Tel1ATM, revealing molecular mechanisms of inhibition and explaining disease-related mutations.

Structural basis of the Cope rearrangement and C-C bond-forming cascade in hapalindole/fischerindole biogenesis

This paper reports the structure of HpiC1, a Stig cyclase involved in hapalindole/fischerindole biosynthesis, revealing its dimeric assembly and key residues for catalytic steps.