Author

K. N. Houk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

M. Garcia-Borras· 2 shared A. Bhattacharya· 1 shared A. N. Lowell· 1 shared C. S. Jamieson· 1 shared D. H. Sherman· 1 shared D. Zhang· 1 shared F. Yu· 1 shared J. L. Smith· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

M. Garcia-Borras

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3 papers

Recent·Most cited

Enzyme-free synthesis of natural phospholipids in water

L. Liu, Y. Zou, A. Bhattacharya, D. Zhang, S. Q. Lang, K. N. Houk, N. K. Devaraj

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

bioRxiv · Sep 5, 2019Biochemistry

Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI

Y. Cai, Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk, J. Zhou, Y. Tang

This paper determines the structural basis for the stereoselective dehydration and hydrogen-bonding catalysis by LepI, revealing how it functions as a multifunctional pericyclase.

bioRxiv · Dec 10, 2018Biochemistry

Structural basis of the Cope rearrangement and C-C bond-forming cascade in hapalindole/fischerindole biogenesis

S. A. Newmister, S. Li, M. Garcia-Borras, J. N. Sanders, S. Yang, A. N. Lowell, F. Yu, J. L. Smith, R. M. Williams, K. N. Houk, D. H. Sherman

This paper reports the structure of HpiC1, a Stig cyclase involved in hapalindole/fischerindole biosynthesis, revealing its dimeric assembly and key residues for catalytic steps.

bioRxiv · Aug 8, 2017Biochemistry