Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires
B. M. Petersen, S. A. Ulmer, E. R. Rhodes, M. F. Gutierrez Gonzalez, B. J. Dekosky, K. G. Sprenger, T. A. Whitehead
The paper predicts framework mutations in therapeutic monoclonal antibodies using natural human antibody repertoires, showing potential to improve antibody properties and reduce immunogenicity.
bioRxiv · Jun 22, 2021Immunology