Author

S. A. Wankowicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:structural biology· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:software / tool· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

J. S. Fraser· 4 shared H. van den Bedem· 3 shared D. A. Keedy· 2 shared D. W. Hogan· 2 shared S. H. P. de Oliveira· 2 shared A. Boosma-Moody· 1 shared A. K. Tewari· 1 shared A. Raju· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

J. S. Fraser

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Author profile →

5 papers

Recent·Most cited

Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM

S. A. Wankowicz, A. Ravikumar, S. Sharma, B. Riley, A. Raju, D. W. Hogan, J. Flowers, H. van den Bedem, D. A. Keedy, J. S. Fraser

This paper introduces enhanced qFit software for building multiconformer models from structural biology data, improving accuracy and usability.

bioRxiv · Jun 28, 2023Biophysics

Refinement of Multiconformer Ensemble Models from Multi-temperature X-ray Diffraction Data

S. Du, S. A. Wankowicz, F. Yabukarski, T. Doukov, D. Herschlag, J. S. Fraser

This study refines multiconformer ensemble models from multi-temperature X-ray diffraction data of Proteinase K, revealing temperature-driven conformational changes and their functional implications.

bioRxiv · May 5, 2023 · PreprintBiophysics

Ligand binding remodels protein side chain conformational heterogeneity

S. A. Wankowicz, S. H. P. de Oliveira, D. W. Hogan, H. van den Bedem, J. S. Fraser

The paper measures conformational heterogeneity of protein side chains in ligand-bound and unbound states and finds that ligand binding increases flexibility in distant residues and correlates with inhibitor properties.

bioRxiv · Sep 21, 2021Biophysics

Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer

A. K. Tewari, A. T. M. Cheung, J. Crowdis, J. R. Conway, S. Y. Camp, S. A. Wankowicz, D. G. Livitz, J. Park, R. T. Lis, A. Boosma-Moody, M. X. He, S. H. AlDubayan, Z. Zhang, R. R. McKay, I. Leshchiner, , E. Van Allen

bioRxiv · Apr 20, 2021Cancer Biology

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps

B. T. Riley, S. A. Wankowicz, S. H. P. de Oliveira, G. C. P. van Zundert, D. Hogan, J. S. Fraser, D. A. Keedy, H. van den Bedem

qFit 3 automates multiconformer modeling of dynamic proteins from X-ray and cryo-EM data, offering improved efficiency and accessibility.

bioRxiv · Sep 3, 2020Biophysics