Author

B. T. Riley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 5 Approach:experimental assay· 4 Assay:protein structure· 4 Approach:statistical model· 3 Assay:structural biology· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 2

Frequent Co-Authors

A. M. Buckle· 5 shared D. A. Keedy· 3 shared D. E. Hoke· 3 shared I. Kass· 3 shared J. Fodor· 3 shared N. A. Borg· 3 shared A. Ebrahim· 2 shared B. T. Porebski· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersBiochemistry

A. M. Buckle

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase

L. Guerrero, A. Ebrahim, B. T. Riley, M. Kim, Q. Huang, A. D. Finke, D. A. Keedy

The paper compares the effects of high temperature and pressure on the structure of the phosphatase STEP, revealing distinct structural changes under each condition.

bioRxiv · May 2, 2023Biophysics

The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)

A. Ebrahim, B. T. Riley, D. Kumaran, B. Andi, M. R. Fuchs, S. McSweeney, D. A. Keedy

This study reports high-resolution crystal structures of SARS-CoV-2 Mpro at various temperatures and humidity, revealing temperature-dependent conformational changes and structural features relevant to antiviral drug development.

bioRxiv · May 3, 2021Biophysics

Mutational and biophysical robustness in a pre-stabilized monobody

P. G. Chandler, L. L. Tan, B. T. Porebski, J. S. Green, B. T. Riley, S. S. Broendum, D. E. Hoke, R. J. Falconer, T. P. Munro, M. Buckle, C. J. Jackson, A. M. Buckle

This paper grafts binding loops from an Adnectin onto a pre-stabilized FN3Con scaffold to create a stable monobody that binds VEGFR2 with high affinity and long-term stability.

bioRxiv · Dec 14, 2020 · PreprintBiochemistry

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps

B. T. Riley, S. A. Wankowicz, S. H. P. de Oliveira, G. C. P. van Zundert, D. Hogan, J. S. Fraser, D. A. Keedy, H. van den Bedem

qFit 3 automates multiconformer modeling of dynamic proteins from X-ray and cryo-EM data, offering improved efficiency and accessibility.

bioRxiv · Sep 3, 2020Biophysics

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

B. T. Riley, O. Ilyichova, S. de Veer, J. swedberg, E. Wilson, D. E. Hoke, J. Harris, A. Buckle

This paper investigates how structural modifications in SFTI-based inhibitors affect their interaction with KLK4, revealing insights into protease inhibition dynamics.

bioRxiv · Mar 8, 2019Biochemistry

The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome

J. Fodor, B. T. Riley, I. Kass, A. M. Buckle, N. A. Borg

This study uses molecular dynamics to show abacavir alters peptide conformations bound to HLA-B*57:01, influencing immune self-reactivity and hypersensitivity.

bioRxiv · Feb 27, 2019Immunology

A metal-dependent switch moderates activity of the hexameric M17 aminopeptidases.

N. Drinkwater, W. Yang, B. T. Riley, B. K. Hayes, K. Kannan Sivaraman, T. R. Malcolm, S. C. Atkinson, N. A. Borg, I. Kass, A. M. Buckle, S. McGowan

This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.

bioRxiv · Feb 21, 2019 · PreprintBiochemistry

Reactive Centre Loop Dynamics and Serpin Specificity

E. M. Marijanovic, J. Fodor, B. T. Riley, B. T. Porebski, M. G. Costa, I. Kass, D. E. Hoke, S. McGowan, A. M. Buckle

This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.

bioRxiv · Aug 14, 2018Biochemistry

Previously Hidden Dynamics at the TCR-pMHC Interface Revealed

J. Fodor, B. T. Riley, N. A. Borg, A. M. Buckle

The paper reveals hidden conformational dynamics in TCR-pMHC interactions using ensemble refinement of X-ray crystallographic data, enhancing functional interpretations of immune responses.

bioRxiv · Feb 21, 2018Immunology