LKB1 acts as a critical brake for the glucagon-mediated fasting response
S. Acevedo-Acevedo, M. L. Stefkovich, S. W. S. Kang, R. P. Cunningham, C. M. Cultraro, N. Porat-Shliom
This study shows LKB1 suppresses the glucagon-induced fasting response in the liver, leading to metabolic inefficiency and prolonged fasting despite increased food intake.
bioRxiv · Jan 29, 2022Physiology