Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme
S. Adak, N. Ye, L. A. Calderone, R. J. B. Schafer, A. L. Lukowski, M.-E. Pandelia, C. L. Drennan, B. S. Moore
This study identifies a novel diiron enzyme, AetD, that catalyzes the oxidative rearrangement of tryptophan to indole nitrile, revealing a new pathway for nitrile biosynthesis.
bioRxiv · Aug 3, 2023 · PreprintBiochemistry