DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2
S. Bjarnason, J. A. P. McIvor, A. Prestel, K. S. Demeny, J. T. Bullerjahn, B. B. Kragelund, D. Mercadante, P. O. Heidarsson
This study shows DNA binding alters the conformational dynamics and accessibility of the IDR in Sox2, affecting activation domains and transcription.
bioRxiv · Jun 16, 2023 · PreprintBiophysics