D. Mercadante

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

This study shows DNA binding alters the conformational dynamics and accessibility of the IDR in Sox2, affecting activation domains and transcription.

The structural, dynamical and biochemical characterizations of Verticillium dahliae pectate lyase, VdPelB, highlight its specificities

This study characterizes VdPelB, a pectate lyase from Verticillium dahliae, revealing its structural, dynamic, and biochemical properties and substrate specificity.

Cortical Dynein Drives Centrosome Clustering in Cells with Centrosome Amplification

The paper shows cortical dynein relocalization is essential for centrosome clustering and bipolar division in cells with extra centrosomes.

Differences in the structure of plant polygalacturonases specify enzymes dynamics and processivities to fine-tune cell wall pectins

This study reports the crystal structures of two Arabidopsis polygalacturonases, showing structural differences that lead to distinct enzyme dynamics and processivities, impacting root development.

Arabidopsis AtPME2 has a pH-dependent processivity and control cell wall mechanical properties

The paper shows AtPME2's pH-dependent processivity affects cell wall mechanical properties and plant development.

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.

This study shows that phosphatidylinositol polyphosphates mediate α-synuclein's plasma membrane localization in multiple cell types.

Modeling Reveals Cortical Dynein-Dependent Fluctuations in Bipolar Spindle Length

The paper develops a computational model to study cortical dynein's role in spindle length fluctuations and bipolarity, showing dynein's necessity in counteracting HSET activity.

Disordered Proteins Enable Histone Chaperoning on the Nucleosome

The paper shows that disordered regions in proteins like H1 enable competitive displacement by histone chaperones such as prothymosin on the nucleosome.

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes

This study shows Aurora A inhibition disrupts spindle pole clustering in cells with supernumerary centrosomes, leading to mitotic catastrophe and aneuploid daughter cells.