Identification of the Intracellular Protein Targets of a Bio-active Clickable Half-Sandwich Iridium Complex by Chemical Proteomics
R. Ramos, A. Karaiskou, C. Botuha, M. Trichet, F. Dingli, J. Forte, F. Lam, A. Canette, C. Chaumeton, M. Salome, T. Chenuel, C. Bergonzi, P. Meyer, S. Bohic, D. Loew, , J. Sobczak-Thepot
This study identifies intracellular protein targets of a clickable iridium complex using chemical proteomics, revealing dual electrophilic and oxidative stress mechanisms.
bioRxiv · May 24, 2023 · PreprintBiochemistry