Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus
H. Elsaman, E. Golubtsov, S. Brazil, N. Ng, I. Klugherz, K. Dichtl, C. Mueller, J. Wagener
This study identifies eburicol accumulation as the mechanism by which azoles exert fungicidal effects against Aspergillus fumigatus, distinct from their action in yeasts.
bioRxiv · Mar 2, 2024Microbiology