Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency
B. M. Lorton, C. Warren, H. Ilyas, P. Nandigrami, S. Hegde, S. Cahill, S. M. Lehman, J. Shabanowitz, D. Hunt, A. Fiser, D. Cowburn, D. Shechter
The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.
bioRxiv · Sep 18, 2023Biochemistry