Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs
C. J. Winski, P. V. Stuckey, A. M. Marrufo, G. Agyei, R. L. Ross, T. Urmi, S. Chapman, F. H. Santiago-Tirado
This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.
bioRxiv · Jun 17, 2024Microbiology