Hsp70 inhibits aggregation of Islet amyloid polypeptide by binding to the heterogeneous prenucleation oligomers
N. Chilukoti, B. Sahoo, D. S, S. Cherakara, M. Maddheshiya, K. Garai
This study shows Hsp70 inhibits IAPP aggregation by binding to oligomers, not monomers, preventing aberrant aggregation while preserving IDP function.
bioRxiv · Mar 30, 2020Biophysics