DYNC1LI2 regulates localization of the chaperone-mediated autophagy-receptor LAMP2A and improves cellular homeostasis in cystinosis
F. Rahman, J. L. Johnson, J. Zhang, J. He, S. Cherqui, S. D. Catz
This study shows that DYNC1LI2 restores endolysosomal dynamics and cellular homeostasis in cystinosis by rescuing LAMP2A localization and reducing ER stress and mitochondrial fragmentation.
bioRxiv · Jun 9, 2020Cell Biology