Snake venom phospholipases A2 possess a strong virucidal activity against SARS-CoV-2 in vitro and block the cell fusion mediated by spike glycoprotein interaction with the ACE2 receptor
A. E. Siniavin, M. A. Nikiforova, S. D. Grinkina, V. A. Gushchin, V. G. Starkov, A. V. Osipov, V. I. Tsetlin, Y. N. Utkin
This study shows that snake venom phospholipases A2, especially dimeric forms, have strong antiviral activity against SARS-CoV-2 by inactivating the virus and blocking cell fusion.
bioRxiv · Jan 12, 2021 · PreprintMicrobiology