Stage-specific ISG expression reveals functional convergence of type I and II IFNs in SIV infection
N. Echebli, N. Tchitchek, S. Dupuy, T. Bruel, C. Pereira Bittencourt Passaes, N. Bosquet, R. Le Grand, C. Bourgeois, B. Favier, R. Cheynier, O. Lambotte, B. Vaslin
The paper analyzes ISG expression in SIV-infected macaques to show that both type-I and type-II IFNs contribute to ISG upregulation, with type-II IFN persisting during chronic infection.
bioRxiv · Sep 22, 2017Immunology