Author

O. Lambotte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:non-human primate· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Saez-Cirion· 2 shared B. Vaslin· 2 shared G. Pancino· 2 shared N. Bosquet· 2 shared R. Le Grand· 2 shared A. Belot· 1 shared A. Blancher· 1 shared A. C. Dufour· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

A. Saez-Cirion

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

C. Cosson, R. Riou, D. Patoli, T. Niu, A. Rey, M. Groslambert, E. Chatre, O. Allatif, T. Henry, F. Venet, F. Milhavet, G. Boursier, A. Belot, Y. Jamilloux, E. Merlin, , B. F. Py

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

bioRxiv · Sep 22, 2023 · PreprintImmunology

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

E. Labaronne, D. Decimo, L. Bertrand, L. Guiguettaz, T. J. Sohier, D. Cluet, V. Vivet-Boubou, C. Dahoui, P. Francois, I. Hatin, O. Lambotte, A. Samri, B. Autran, L. Etienne, C. Goujon, , E. Ricci

The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.

bioRxiv · Apr 29, 2022Microbiology

HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes

C. Inizan, M. Caillet, A. Desrames, P. Bomme, A. MALLET, K. Bourdic, O. Lambotte, F. Boufassa, M. Mesel-Lemoine, F. Tangy, G. Pancino, H. Mouquet, t. Lagache, A. C. Dufour, J.-C. Olivo-Marin, , M.-I. Thoulouze

This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.

bioRxiv · Sep 27, 2021 · PreprintMicrobiology

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

C. Passaes, A. Millet, V. Madelain, V. Monceaux, A. David, P. Versmisse, N. Sylla, E. Gostick, D. A. Price, A. Blancher, N. Bosquet, G. Pancino, R. Le Grand, O. Lambotte, M. Muller-Trutwin, , A. Saez-Cirion

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.

bioRxiv · Dec 20, 2019Immunology

Stage-specific ISG expression reveals functional convergence of type I and II IFNs in SIV infection

N. Echebli, N. Tchitchek, S. Dupuy, T. Bruel, C. Pereira Bittencourt Passaes, N. Bosquet, R. Le Grand, C. Bourgeois, B. Favier, R. Cheynier, O. Lambotte, B. Vaslin

The paper analyzes ISG expression in SIV-infected macaques to show that both type-I and type-II IFNs contribute to ISG upregulation, with type-II IFN persisting during chronic infection.

bioRxiv · Sep 22, 2017Immunology