R. Le Grand

Optimization of neuromuscular blockade protocols in cynomolgus macaques: monitoring, doses and antagonism

This study evaluates neuromuscular blockade in cynomolgus macaques using rocuronium and atracurium, finding equivalent blockade depth at human clinical doses and successful reversal with sugammadex.

Multi-target mode of action of Sulfodyne(R), a stabilized Sulforaphane, against pathogenic effects of SARS-CoV-2 infection

This paper shows that Sulfodyne(R), a stabilized Sulforaphane, reduces SARS-CoV-2-induced inflammation and disease severity in cell lines and animal models through mechanisms independent of NRF2 activation.

Multimodal mucosal and systemic immune characterization of a novel non-human primate trachoma model highlights the critical role of local immunity during acute phase disease

This study develops a non-human primate model of acute trachoma and characterizes the local immune response kinetics following Chlamydia trachomatis infection.

Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection

This study uses mathematical modeling of SIV-infected macaques to show that early CD8 T-cell suppressive capacity predicts natural control of infection.

Seminal plasma inhibits Chlamydia trachomatis infection in vitro, and may have consequences on mucosal immunity

This study shows that seminal plasma inhibits Chlamydia trachomatis infection and modulates neutrophil function in an in vitro model of the female reproductive tract.

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection

This study identifies P2X7 and NLRP3 inflammasome as host factors required for SARS-CoV-2 infection and shows their role in promoting viral replication.

A novel adjuvant formulation induces robust Th1/Th17 memory and mucosal recall responses in Non-Human Primates

This paper develops a novel liposomal adjuvant, CAF(R)10b, that induces robust Th1/Th17 memory and mucosal recall responses in non-human primates.

Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model

This study shows Sotrovimab remains effective against SARS-CoV-2 BQ.1.1 in a non-human primate model, as measured by reduced viral replication.

Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.

This study examines how SARS-CoV-2 variants of concern affect viral dynamics in non-human primates, finding that most variants escape immune responses, with delta and omicron showing significant differences in viral production rates.

SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines

A mathematical model of viral dynamics is used to identify mechanistic correlates of protection in SARS-CoV-2 vaccines across three non-human primate studies.

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

This study shows that subcutaneous vaccine administration leads to long-term phenotypic changes in blood neutrophils, unlike intradermal administration, highlighting the role of delivery route in immune training.

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

This study shows that Artemisia infusions inhibit Plasmodium stages without artemisinin, suggesting potential for new antimalarial compounds.

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

Modeling SIV dynamics in natural controller macaques shows viral control is driven by early cytotoxic T-cell response and reveals distinct infected cell compartments with different turnover rates.

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.

Targeting MOG to skin macrophages prevents EAE in macaques through TGFβ-induced peripheral tolerance

This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.

Stage-specific ISG expression reveals functional convergence of type I and II IFNs in SIV infection

The paper analyzes ISG expression in SIV-infected macaques to show that both type-I and type-II IFNs contribute to ISG upregulation, with type-II IFN persisting during chronic infection.