Pairing to the microRNA 3' region occurs through two alternative binding modes, with affinity shaped by nucleotide identity as well as pairing position
S. E. McGeary, N. Bisaria, D. P. Bartel
This study measures the affinity of miRNA 3'-pairing architectures using RNA bind-n-seq, revealing two binding modes and the role of nucleotide identity in shaping pairing preferences.
bioRxiv · Apr 13, 2021Biochemistry