Author

D. P. Bartel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

N. Bisaria· 2 shared S. E. McGeary· 2 shared C. Y. Shi· 1 shared K. S. Lin· 1 shared P. Y. Wang· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

N. Bisaria

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3 papers

Recent·Most cited

The guide RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex

P. Y. Wang, D. P. Bartel

The paper shows guide RNA sequence affects slicing rates and conformational dynamics of the Argonaute complex, with sequence variations influencing slicing efficiency and 3'-mismatch tolerance.

bioRxiv · Oct 15, 2023Biochemistry

Pairing to the microRNA 3' region occurs through two alternative binding modes, with affinity shaped by nucleotide identity as well as pairing position

S. E. McGeary, N. Bisaria, D. P. Bartel

This study measures the affinity of miRNA 3'-pairing architectures using RNA bind-n-seq, revealing two binding modes and the role of nucleotide identity in shaping pairing preferences.

bioRxiv · Apr 13, 2021Biochemistry

The biochemical basis of microRNA targeting efficacy

S. E. McGeary, K. S. Lin, C. Y. Shi, N. Bisaria, D. P. Bartel

This study measures miRNA-target binding affinities using RNA bind-n-seq and builds a model to predict miRNA-mediated repression.

bioRxiv · Sep 11, 2018Biochemistry