E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.
A. Verma, B. Aylward, F. Ma, C. A. Sherman, L. Chopp, S. Shinton, R. Roy, S. Fahl, A. Contreras, B. Koenitzer, P. Awasthi, K. Mazan-Mamczarz, S. De, N. Ollikainen, X. Qiu, , J. M. Sen
This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.
bioRxiv · Nov 6, 2023 · PreprintImmunology