Author

J. M. Sen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Karimi· 3 shared M. Mammadli· 3 shared R. Harris· 3 shared A. May· 2 shared A. Verma· 2 shared Q. Yang· 2 shared A. Contreras· 1 shared A. T. Waickman· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

M. Karimi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

A. Verma, B. Aylward, F. Ma, C. A. Sherman, L. Chopp, S. Shinton, R. Roy, S. Fahl, A. Contreras, B. Koenitzer, P. Awasthi, K. Mazan-Mamczarz, S. De, N. Ollikainen, X. Qiu, , J. M. Sen

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

bioRxiv · Nov 6, 2023 · PreprintImmunology

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

M. Mammadli, R. Harris, S. Mahmudlu, A. Verma, A. May, R. Dhawan, A. T. Waickman, J. M. Sen, M. Karimi

This study shows that β-catenin regulates donor T cells in allo-HSCT, reducing GVHD while preserving GVL effects through altered cytokine production and cytotoxicity.

bioRxiv · Apr 12, 2021 · PreprintImmunology

TCF-1 in CD4 T cells regulates GVHD severity and persistence

R. Harris, M. Mammadli, A. May, Q. Yang, I. T. H. Fung, J. M. Sen, M. Karimi

This study shows that loss of TCF-1 in mature CD4 T cells reduces GVHD severity and persistence by impairing T cell function and increasing exhaustion.

bioRxiv · Mar 22, 2021 · PreprintImmunology

TCF-7 is dispensable for the anti-tumor response but required for the persistent function of mature CD8 T cells

R. Harris, M. Mammadli, S. Hiner, Q. Yang, J. M. Sen, M. Karimi

This study shows TCF-7 is not needed for anti-tumor response but is required for long-term function of mature CD8 T cells.

bioRxiv · Mar 22, 2021 · PreprintImmunology