Elevated pyrimidine dimer formation at distinct genomic bases underlie promoter mutation hotspots in UV-exposed cancers
K. Elliott, M. Bostrom, S. Filges, M. Lindberg, J. Van den Eynden, A. Stahlberg, A. R. Clausen, E. Larsson
The paper shows that UV-induced mutations in cancer promoters are due to base-specific increases in pyrimidine dimer formation, not inhibited repair.
bioRxiv · Aug 31, 2018Cancer Biology